2016 will introduce healthcare organizations to the empowered patient, triggering changes across technology and business models. In response to this changing landscape, CIOs will face increased demands for interoperability, security, and infrastructure updates related to mergers and acquisitions (M&As) as well as for an improved business technology (BT) agenda. This brief gives CIOs an overview of the major issues that healthcare CIOs will face in 2016 in the realms of data, patient expectations, and where and when patients get care.