Wyeth Pharmaceuticals recently completed a major upgrade to its business-to-business (B2B) capability that supports a global rollout of a single-instance SAP implementation. The upgrade resulted in a more agile B2B operation, labor savings in excess of 60% per year, and reduced software licensing costs in the range of 20% per year. Enterprise architects should use Wyeth's experience as an example of the types of savings that B2B modernization efforts can provide.