In 2010, Sanofi, a large multinational in the healthcare market, embarked on a business transformation in response to increasing market complexity. Similar market complexities are affecting most industries, and businesswide transformation is key to addressing these challenges. In particular, infrastructure and operations (I&O) transformation should concentrate on shifting from a reactive to a proactive approach focused on satisfying customer requirements and increasing business competitiveness. This Forrester case study provides a blueprint for successfully transforming the I&O organization from a siloed approach to a global, integrated structure and addresses necessary changes to people, process, and technology.