Application integration is a perennial challenge for solution architects and developers, and it's only getting worse with software-as-a-service (SaaS) adding more point solutions to the mix and mobile adding more integration requirements. Forrester's integration vision for the next decade — digital business design — charts a path forward through the complexity: Put business design at the center of integration strategy, and thereby achieve coherent business operations in spite of application and technology silos. This report describes how four organizations are applying business-centered design to their application integration efforts and, as a result, improving agility for ongoing optimization of operations and creation of new customer insights.