US president Donald Trump is heralding or taking actions that will redefine the environment for US-based and global businesses. The administration could fundamentally alter policy, regulations, and treaties in domains like trade and immigration — creating real uncertainty and exacerbating firms' ongoing scramble to become customer-obsessed and fend off digital insurgents. This report provides a macro view of the changing policy domains likely to affect business strategies and identifies actions customer-obsessed firms should take to anticipate and respond to new challenges and opportunities.