Vaccine passports promise to quickly turn hope into a reality, including bringing employees back to the physical workplace. Despite the high expectations, employers must be cautious as they plan and execute their pandemic management plans. Changes to their pandemic protocols must be moderate, not radical. They must still contend with many unanswered questions related to vaccine effectiveness, its deployment timeline, and the impact of geographical variations. As they contemplate leveraging vaccine passports for pandemic response, employers must deal with an array of unique privacy and ethical concerns, legal and compliance considerations, and other operational risks.