Business and technology leaders in asset-intensive industries like manufacturing have had another difficult year, and plenty of challenges await them in 2022. The most successful leaders are operationalizing lessons from the pandemic to pull ahead as their less confident peers fall back into old habits. Geopolitical tensions will complicate operations but create opportunities as governments invest to attract manufacturing capacity. And sustainability is moving from a nice-to-have to become a key element in future planning. In this report, we explore Forrester’s predictions for smart manufacturing in 2022.