The pace of change for healthcare organizations (HCOs) in 2025 is causing significant volatility in the industry. HCOs’ lack of agility and preparedness is amplifying the impact and uncertainty. To stay resilient and unified, HCOs must employ nimble strategies and scenario planning to succeed amid today’s ongoing changes and beyond. Reflecting on past events and lessons learned, this report provides 10 practical steps for HCOs to create a path forward and remain focused on their core mission.