Agencies must embark on a quest to regain relevance in 2021. Virtual workplaces and an emphasis on digital execution point to more mingling of technology and talent; AI and intelligent automation will make agencies smaller but smarter. Savvy CMOs will focus on building business value beyond just marketing and release their hold on agency activities, freeing agencies to prospect opportunities from other members of the C-suite and lines of business across the organization. In this report, we explore Forrester's predictions for agencies in 2021.