Business leaders target globalization to deliver performance that spans geographic and organizational boundaries. What globalization means for CIOs is not simple — they have to help their firms deliver optimized global performance while meeting local needs and responding to constant business change — all while helping keep business innovation alive and well. Making this happen requires CIOs to handle the global-local matrix through key global functions, connect global capabilities and local needs, use technologies that enable both integration and agility, and employ communication to create and maintain trust.