Customer obsession has created a business environment of continual disruption. Constant change is forcing execs to recognize that traditional planning and delivery practices don't sustain the ability to focus on strategy while delivering new capabilities. To adapt to an environment where change is the new normal, project management office (PMO) leaders and enterprise architecture (EA) strategists are expanding Agile methods, but scaling Agile to the enterprise requires significant process, organization, and cultural change. This report identifies best practices for tackling this challenge.