The key challenge that will embroil healthcare organizations in 2022 is preservation — preservation of balance sheets strained by delayed procedures and hospital closures, of a workforce dealing with massive flight, and of public trust that is actively eroded by malevolent actors and misinformation. Healthcare leaders must tackle these challenges head-on to provide equitable, culturally competent care. Evolving care modalities and preferences, like hospital at home and virtual mental health, will permanently alter how and when patients receive care. This report explores Forrester’s predictions for healthcare in 2022.