Best-in-class organizations regularly analyze the offerings in their current portfolio to guide decision-making on product strategy investment. When B2B organizations have too many offerings available, buyers become confused, sales reps lose focus and marketing dollars lose impact. Product management should assess in-market products at least once or twice a year, with participation from marketing and sales. This report introduces the Product Portfolio Optimization Framework, which is used to assess the current state of commercially released products, services, and solutions across five dimensions: market, strategic, competitive, commercial, and financial.