As CMOs prepare for 2022, they are facing a situation unlike any they have ever encountered. The companies that have best navigated the past year have aligned their sales, marketing, product, and customer functions before or in the early stages of the pandemic-driven market disruption. These organizations balanced investments across existing and new customers, took a customer-first approach to developing genuine and empathetic relationships, and measured performance against aligned corporate and functional goals instead of siloed measures. In this report, we identify five trends that will define the priorities B2B CMOs must address to ensure success for their organizations in 2022.